Alexander Kurosky, Ph.D.

University of Texas System Proteomics Core Facility Network

UTMB Biomolecular Resource Facility

NIEHS Center in Environmental Toxicology

Publications (Pubmed)

Affiliations: Department of Biochemistry & Molecular Biology; Director UTMB Biomolecular Resource Facility; Sealy Centers for Molecular Medicine and for Environmental Health & Medicine
Tel: (409) 772-2771
Fax: (409) 772-8205
akurosky@utmb.edu
Route: 0645
1.106 Basic Science Building

 

 

 

 

Alexander Kurosky, Ph.D.

Professor

Dr. Kurosky’s laboratory has focused over the years on protein structure, function, and genetics, relating to plasma proteins, bacterial toxins, proprotein processing and airway inflammation. More recently the laboratory has transitioned into the discipline of proteomics and is pursing both proteomics technology development as well as directed proteomics research to investigate total protein expression to obtain a more global understanding of biological phenomena. Dr. Kurosky is also Director of the UTMB Biomolecular Resource Facility (BRF), a University-wide facility that includes several component infrastructure cores, largely dedicated to the production and/or analysis of proteins and peptides. Recently Dr. Kurosky was awarded a UT System grant to develop a proteomics network within the six medical schools and nine academic institutions in the UT System.

A major ongoing project in Dr. Kurosky’s laboratory relates to a better understanding of the biology of eosinophils and their involvement in inflammatory diseases. Eosinophils are bone marrow-derived granulocytes that are abundant in inflammatory infiltrates of many pathologic processes, such as allergic diseases, e.g. asthma. Eosinophil maturation from myeloid precursors is promoted by cell signaling events as a consequence of the action of GM-CSF, IL3, and IL-5. As a foundation for these studies the laboratory is pursuing defining cell signaling phenomena. Thus, cytokine function defined within a context of phosphoproteomics is an integral part of these eosinophil-related studies. Important also to these studies are the structure and function of protein complexes found in eosinophils and their subsequent alteration in various disease states, including component kinetic flux. Overall these studies employ a variety of protein fractionation and characterization technologies, especially mass spectrometry, and extensively utilized ¬†¬†bioinformatics to analyze and interpret the considerable amount of data generated by these studies.

Kurosky